Spray adhesive and fixative should be used ________________.

Using spray adhesive and fixative in a well-ventilated area is essential due to the potential presence of harmful fumes and chemicals that can be released during application. Proper ventilation helps to dissipate these vapors and minimizes the risk of inhalation, ensuring a safer working environment. Adequate airflow can aid in reducing the concentration of airborne particles and volatile organic compounds (VOCs) that may be harmful to health.

The other options suggest practices that are less safe or less practical. Applying these products under any condition could expose individuals to harmful fumes without consideration for safety measures. Using them only outdoors might not always be feasible or necessary, especially if a suitable indoor space can be adequately ventilated. Lastly, working without protective gear such as masks or gloves increases the risk of skin and respiratory irritation, which is contrary to best practices in safety.